EXCLI Journal is particularly keen to keep a broad view of science and technology, and therefore welcomes papers which bridge disciplines and may not suit the narrow specialism of other journals. Although the general emphasis is on biological sciences, studies from the following fields are explicitly encouraged:Immunology, toxicology, ergonomics, neurosciences, psychology, occupational medicine, clinical and preclinical studies, drug development, pharmacology, environmental health, chemistry including analytical chemistry, biochemistry, cell biology, genetics, forensic medicine, oncology and cancer research, proteomics, systems biology, hepatology and gastroenterology, aging research, psychiatric research, behavioral sciences.

EXCLI雜志尤其熱衷于保持廣泛的科學和技術,因此歡迎論文橋梁學科,可能不適合其他期刊的狹窄的特長。雖然一般的重點是生物科學，但明確鼓勵下列領域的研究:免疫學、毒理學、工效學、神經科學、心理學、職業醫學、臨床和臨床前研究、藥物開發、藥理學、環境衛生、化學包括分析化學、生物化學、細胞生物學、遺傳學、法醫學、腫瘤學和癌癥研究、蛋白質組學、系統生物學、肝腸病學、衰老研究、精神病學研究、行為科學。