The Journal publishes research results dealing with the chemistry and biochemistry of agriculture and food with a focus on original research representing complete studies, rather than incremental studies. Topics covered include chemical/biochemical composition and the effects of processing on the composition and safety of foods, feeds, and other products from agriculture, including wood and other bio-based materials, byproducts, and wastes. It covers the chemistry of pesticides, veterinary drugs, plant growth regulators, fertilizers, and other agro-chemicals, together with their metabolism, toxicology, and environmental fate. In addition, JAFC reports on the chemical processes involved in nutrition, phytonutrients, flavors, and aromas.

該雜志發表了有關農業和食品化學和生物化學的研究結果，重點是代表完整研究的原始研究，而不是增量研究。所涵蓋的主題包括化學/生物化學成分以及加工對食品、飼料和其他農業產品（包括木材和其他生物基材料、副產品和廢物）的成分和安全性的影響。它包括殺蟲劑、獸藥、植物生長調節劑、化肥和其他農用化學品的化學成分，以及它們的新陳代謝、毒理學和環境命運。此外，JAFC還報道了營養、植物營養、香料和香味的化學過程。