Organic & Biomolecular Chemistry (OBC) publishes original and high impact research and reviews in organic chemistry.We welcome research that shows new or significantly improved protocols or methodologies in total synthesis, synthetic methodology or physical and theoretical organic chemistry as well as research that shows a significant advance in the organic chemistry or molecular design aspects of chemical biology, catalysis, supramolecular and macromolecular chemistry, theoretical chemistry, mechanism-oriented physical organic chemistry, medicinal chemistry or natural products.Articles published in the journal should report new work which makes a highly-significant impact in the field. Routine and incremental work is generally not suitable for publication in the journal.More details about key areas of our scope are below. In all cases authors should include in their article clear rationale for why their research has been carried out.Organic synthesis: We welcome important research in all areas of organic synthesis, including studies on small organic molecules and biomolecules, and studies that report purely synthetic work without biological data. Total or multistep syntheses should report new or improved strategies or methods, or a more efficient route to the target compound. Methodology studies should show a significant improvement on known methods. Research that extends known methodology to a different class of compounds is generally not suitable, unless that class is significantly different in scope to previously reported methodology.Physical and theoretical organic chemistry: We welcome studies that report new models of reactivity, selectivity, bonding or structure, or new computational methods and have relevance for the design of subsequent experiments. That relevance should be clearly justified in the paper. Relevance is perhaps most clearly demonstrated by the description of testable predictions derived from the results of the reported theoretical work; the tests of these predictions could be contained in the same paper in which the predictions are described. Computational research that merely reproduces experimental data is not suitable for OBC.Chemical biology: We welcome articles that report new or improved methodologies in the chemical aspects of chemical biology, including design, development and use of chemical tools, chemical studies of biomolecules such as carbohydrates, proteins and nucleic acids or biological processes such as protein-protein interactions and epigenetics, and chemical methods such as imaging and labelling techniques.Supramolecular, macromolecular and organic materials: We welcome studies that report important new work in the molecular design of supramolecular or macromolecular compounds or organic materials either with a strong component in organic synthesis or with novel organic structural features. You may wish to consider our materials journals for articles outside this scope.Sensors: We publish articles describing sensors for ions and/or molecules provided that: (a) they address targets and situations of practical relevance; and (b) they represent significant and demonstrable improvements on previous methodology. In particular, sensors for species in artificial surroundings (for example, hydrophilic ions in organic solvents) will not typically be acceptable for publication.Medicinal chemistry: We welcome studies that report significant synthetic or bioorganic research that is directed towards medicinal chemistry applications. Studies that show routine syntheses accompanied by biological testing are generally not suitable for OBC. Our sister journal, MedChemComm, is more suitable for articles that report significant research in core medicinal chemistry disciplines.Natural products: We welcome articles that report new and interesting syntheses of natural products (see Organic Synthesis guidelines above) or chemical studies of biosynthetic pathways. Isolation or identification studies are welcome when the compound being reported:1) Has a novel structural class with unreported carbon skeleton, unusual functional groups or unusual modifications and/or2) Displays a potent or unexpected biological activity or an unexpected mechanism of action. Routine isolation studies are not suitable for OBC.

有機與生物分子化學(xué)（OBC）出版了有機化學(xué)的原始和高影響的研究和評論。我們歡迎在全合成、合成方法或物理和理論有機化學(xué)方面顯示出新的或顯著改進的方案或方法的研究，以及在化學(xué)生物學(xué)、催化、超分子和大分子C的有機化學(xué)或分子設(shè)計方面顯示出顯著進步的研究?；瘜W(xué)、理論化學(xué)、機制物理有機化學(xué)、藥物化學(xué)或天然產(chǎn)物。雜志上發(fā)表的文章應(yīng)該報道在這一領(lǐng)域產(chǎn)生重大影響的新工作。常規(guī)工作和增量工作通常不適合在期刊上發(fā)表。關(guān)于我們范圍的關(guān)鍵領(lǐng)域的更多細節(jié)如下。在所有情況下，作者都應(yīng)該在他們的文章中清楚地說明為什么要進行研究。有機合成：我們歡迎在所有有機合成領(lǐng)域的重要研究，包括小有機分子和生物分子的研究，以及在沒有生物數(shù)據(jù)的情況下報告純合成工作的研究?？偤铣苫蚨嗖襟E合成應(yīng)報告新的或改進的策略或方法，或更有效的途徑到目標(biāo)化合物。方法學(xué)研究應(yīng)該顯示出對已知方法的顯著改進。將已知方法擴展到不同類別的化合物的研究通常是不合適的，除非該類別在范圍上與先前報告的方法有顯著不同。物理和理論有機化學(xué)：我們歡迎報告反應(yīng)性、選擇性、鍵合或結(jié)構(gòu)的新模型或新計算方法的研究，并與后續(xù)實驗的設(shè)計有關(guān)聯(lián)。這一相關(guān)性應(yīng)該在論文中得到明確的證明。從報告的理論工作的結(jié)果中得出的可測試預(yù)測的描述可能最清楚地證明了相關(guān)性；這些預(yù)測的測試可以包含在描述預(yù)測的同一篇論文中。僅僅復(fù)制實驗數(shù)據(jù)的計算研究不適用于OBC?；瘜W(xué)生物學(xué)：我們歡迎在化學(xué)生物學(xué)的化學(xué)方面報道新的或改進的方法的文章，包括化學(xué)工具的設(shè)計、開發(fā)和使用，碳水化合物、蛋白質(zhì)和核酸等生物分子的化學(xué)研究，或蛋白質(zhì)-蛋白質(zhì)相互作用和表觀遺傳學(xué)等生物過程，以及化學(xué)方法，如成像和標(biāo)記技術(shù)。超分子、大分子和有機材料：我們歡迎在超分子或大分子化合物或有機材料的分子設(shè)計中報告重要新工作的研究，無論是有機合成中的強組分還是具有新的有機結(jié)構(gòu)特征。您可能希望考慮我們的材料期刊以外的文章這一范圍。傳感器：我們發(fā)表的文章描述了離子和/或分子的傳感器，前提是：（a）它們解決了與實際相關(guān)的目標(biāo)和情況；（b）它們代表了對以前方法的顯著和可證明的改進。特別是，人工環(huán)境中物種的傳感器（例如有機溶劑中的親水離子）通常不可用于出版。藥物化學(xué)：我們歡迎報道針對藥物化學(xué)應(yīng)用的重要合成或生物有機研究的研究。研究表明，常規(guī)合成和生物測試通常不適用于OBC。我們的姊妹期刊Medchemcomm更適合報道在核心藥物化學(xué)學(xué)科的重要研究的文章。天然產(chǎn)物：我們歡迎報道新的和有趣的天然產(chǎn)物合成（見上文有機合成指南）或生物合成途徑化學(xué)研究的文章。當(dāng)所報告的化合物：1）具有新的結(jié)構(gòu)類別，具有未報告的碳骨架、異常功能組或異常修改和/或2）表現(xiàn)出一種強有力或意想不到的生物活性或意想不到的作用機制。常規(guī)隔離研究不適用于OBC。